Protein level identification of the Listeria monocytogenes Sigma H, Sigma L, and Sigma C regulons

Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes.

Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternat...

The alternative sigma factor sigma B and the virulence gene regulator PrfA both regulate transcription of Listeria monocytogenes internalins.

Some Listeria monocytogenes internalins are recognized as contributing to invasion of mammalian tissue culture cells. While PrfA is well established as a positive regulator of L. monocytogenes virulence gene expression, the stress-responsive sigma(B) has been recognized only recently as contributing to expression of virulence genes, including some that encode internalins. To measure the relativ...

APPROXIMATELY INNER sigma-DYNAMICS ON C* ALGEBRAS

approximately inner sigma-dynamics on c* algebras

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Identification of the Patient Requirements Using Lean Six Sigma and Data Mining

Lean health care is one of new managing approaches putting the patient at the core of each change. Lean construction is based on visualization for understanding and prioritizing imporvments. By using only visualization techniques, so much important information could be missed. In order to prioritize and select improvements, it’s essential to integrate new analysis tools to achieve a good unders...